Histone methylation has emerged as an important mechanism for regulating the transcriptional
accessibility of chromatin. Several methyltransferases have been shown to target histone …

In Alzheimer's disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that
spread retrogradely by unknown mechanisms, affecting the entire neuron. We found that …

Epigenetic modifications of chromatin serve an important role in regulating the expression
and accessibility of genomic DNA. We report here a genomewide approach for fractionating …

Huns, Avars, and conquering Hungarians were migration-period nomadic tribal confederations
that arrived in three successive waves in the Carpathian Basin between the 5 th and 9 th …

Background Molecular characterization has the potential to advance the management of
pediatric cancer and high-risk hematologic disease. The clinical integration of genome …

Autosomal recessive Stargardt disease (STGD1, MIM 248200) is caused by mutations in the
ABCA4 gene. Complete sequencing of ABCA4 in STGD patients identifies compound …

Glc7, the yeast protein phosphatase 1, is a component of the cleavage and polyadenylation
factor (CPF). Here we show that downregulation of Glc7, or its dissociation from CPF in the …

Objectives: To characterize the prevalence of cognitive and behavioral symptoms using a
cognitive/behavioral screening battery in a large prospective multicenter study of amyotrophic …

Transcription of the Bacillus subtilis pur operon is repressed in response to a signal of
excess adenine. We have purified the repressor protein and have identified, cloned, and …

Mutations in the LMNA gene, which encodes A-type nuclear lamins (intermediate filament
proteins expressed in most differentiated somatic cells), cause a diverse range of diseases, …