The rapid development of angiogenic growth factor therapy for patients with advanced
ischemic heart disease over the last 5 years offers hope of a new treatment strategy based on …

The incidence of valvular heart disease is expected to increase over the next several decades
as a large proportion of the US demographic advances into the later decades of life. At the …

Sepsis is a common clinical entity causing thousands of deaths and costing billions of
healthcare dollars annually in the US alone [1–4]. Further, sepsis and septic shock represent a …

Background—Therapeutic angiogenesis, a new experimental strategy for the treatment of
vascular insufficiency, uses the administration of mediators known to induce vascular …

Ischemic tissues require mechanisms to alert the immune system of impending cell damage.
The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory …

Background and Purpose— The purpose of this study was to describe prognostic factors for
outcome in a large series of patients undergoing neurosurgical clipping of aneurysms after …

Background After a person has been injured, prehospital administration of plasma in addition
to the initiation of standard resuscitation procedures in the prehospital environment may …

Omentum has been used clinically to promote wound healing and to stimulate the
revascularization of ischemic tissues. The biologic mechanism responsible for these effects has, …

Objective Since the pioneering era of E. Stanley Crawford, our multimodal strategy for
thoracoabdominal aortic aneurysm repair has evolved. We describe our approximately 3-decade …

Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. …