The quiescent state is thought to be an indispensable property for the maintenance of
hematopoietic stem cells (HSCs). Interaction of HSCs with their particular microenvironments, …

Osteoclasts are terminally differentiated cells derived from hematopoietic stem cells. However,
how their precursor cells diverge from macrophagic lineages is not known. We have …

Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood
production for their lifetime 1 . Appropriate control of HSC self-renewal is crucial for the …

The ‘ataxia telangiectasia mutated’ (Atm) gene maintains genomic stability by activating a
key cell-cycle checkpoint in response to DNA damage, telomeric instability or oxidative stress …

Hematopoietic stem cells (HSCs) are maintained in an undifferentiated quiescent state within
a bone marrow niche. Here we show that Foxo3a, a forkhead transcription factor that acts …

Maintenance of hematopoietic stem cells (HSCs) depends on interaction with their niche.
Here we show that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor, …

Perichondrium in fetal limb is composed of undifferentiated mesenchymal cells. However, the
multipotency of cells in this region and the role of perichondrium in bone marrow formation …

Stem-cell function is an exquisitely regulated process. Thus far, the contribution of metabolic
cues to stem-cell function has not been well understood. Here we identify a previously …

Type I interferons (IFNs), a family of cytokines, orchestrate numerous biological and cellular
processes 1 , 2 , 3 . Although it is well known that type I IFNs are essential for establishing …

Hematopoietic stem cells (HSCs) are responsible for blood cell production throughout an
individual's lifetime. Interaction of HSCs with their specific microenvironments, known as stem …