Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is
impacted by other common tumor mutations is not known. In apoptosis-defective cells, …

The purpose of these guidelines is to provide concise guidance on the planning, performing
and interpretation of studies to monitor groups or individuals exposed to genotoxic agents. …

The wide scale use of Zinc oxide (ZnO) nanoparticles in the world consumer market makes
human beings more prone to the exposure to ZnO nanoparticles and its adverse effects. The …

The comet assay is a versatile method to detect nuclear DNA damage in individual eukaryotic
cells, from yeast to human. The types of damage detected encompass DNA strand breaks …

A number of tests have been described which are thought to be capable of identifying
carcinogens without using the actual induction of cancer as an endpoint. This study compared the …

The following summary represents a consensus of the working group except where noted.
The items discussed are listed in the order in which they appear in the OECD guideline (474) …

Cyclophosphamide (CP) is used to treat a wide range of neoplastic diseases as well as some
non-malignant ones such as rheumatoid arthritis. It is also used as an immunosuppressive …

Objective: To develop a guideline to help guide healthcare professionals participate effectively
in the design, construction, and occupancy of a new or renovated intensive care unit. …

Genomic instability is a hallmark of cancer development and progression, and characterizing
the stresses that create and the mechanisms by which cells respond to genomic …

Invadopodia are actin-rich membrane protrusions of cancer cells that facilitate pericellular
proteolysis and invasive behavior. We show here that reactive oxygen species (ROS) …