Angiogenesis is controlled by physical interactions between cells and extracellular matrix
as well as soluble angiogenic factors, such as VEGF. However, the mechanism by which …

Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development. …

Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …

Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary
interface of the human lung. This bioinspired microdevice reproduces complex …

Mesenchymal condensation is critical for organogenesis, yet little is known about how this
process is controlled. Here we show that Fgf8 and Sema3f, produced by early dental …

Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its
progression-free survival. However, current antiangiogenic therapy induces serious adverse …

Increased vascular permeability contributes to many diseases, including acute respiratory
distress syndrome, cancer and inflammation. Most past work on vascular barrier function has …

The Rho GDP dissociation inhibitor (GDI) forms a complex with the GDP-bound form of the
Rho family small G proteins and inhibits their activation. The GDP-bound form complexed …

Abstract Development and regeneration of tissues and organs require precise coordination
among endothelial, epithelial and mesenchymal morphogenesis. Angiogenesis plays key …

Current in vitro hematopoiesis models fail to demonstrate the cellular diversity and complex
functions of living bone marrow; hence, most translational studies relevant to the …