Intercellular transfer of microvesicles from young mesenchymal stromal cells rejuvenates aged murine hematopoietic stem cells
R Kulkarni, M Bajaj, S Ghode, S Jalnapurkar…�- Stem Cells, 2018 - academic.oup.com
Donor age is one of the major concerns in bone marrow transplantation, as the aged
hematopoietic stem cells (HSCs) fail to engraft efficiently. Here, using murine system, we show that …
hematopoietic stem cells (HSCs) fail to engraft efficiently. Here, using murine system, we show that …
Monitoring of lateral and cross level track geometry irregularities through onboard vehicle dynamics measurements using machine learning classification algorithms
A De Rosa, R Kulkarni, A Qazizadeh…�- Proceedings of the�…, 2021 - journals.sagepub.com
In recent years, significant studies have focused on monitoring the track geometry irregularities
through measurements of vehicle dynamics acquired onboard. Most of these studies …
through measurements of vehicle dynamics acquired onboard. Most of these studies …
Investigating the effect of the equivalent conicity function's nonlinearity on the dynamic behaviour of a rail vehicle under typical service conditions
R Kulkarni, A Qazizadeh, M Berg, B Dirks…�- Vehicle System�…, 2022 - Taylor & Francis
Generally, the equivalent conicity function (ECF) is denoted by equivalent conicity at 3mm (λ
3mm ) and a Nonlinearity Parameter (NP). NP describes the nonlinearity of the ECF and its …
3mm ) and a Nonlinearity Parameter (NP). NP describes the nonlinearity of the ECF and its …
[HTML][HTML] Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation
LN Segal, AV Alekseyenko, JC Clemente, R Kulkarni…�- Microbiome, 2013 - Springer
Background The lung microbiome of healthy individuals frequently harbors oral organisms.
Despite evidence that microaspiration is commonly associated with smoking-related lung …
Despite evidence that microaspiration is commonly associated with smoking-related lung …
[HTML][HTML] Plasma microbiome-modulated indole-and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes
…, KT Dolan, G Sharma, M Tao, R Kulkarni…�- Journal of vascular�…, 2018 - Elsevier
Objective Multiple studies have shown that gut microbes contribute to atherosclerosis, and
there is mounting evidence that microbial metabolism of dietary nutrients influences …
there is mounting evidence that microbial metabolism of dietary nutrients influences …
Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing
…, RR Young, MR Fielden, R Kulkarni…�- Proceedings of the�…, 2020 - pnas.org
The ability to accurately measure mutations is critical for basic research and identifying
potential drug and chemical carcinogens. Current methods for in vivo quantification of …
potential drug and chemical carcinogens. Current methods for in vivo quantification of …
[HTML][HTML] Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters
…, M Martinez-Paniagua, A Damian, R Kulkarni…�- Nature�…, 2024 - nature.com
Immunization programs against SARS-CoV-2 with commercial intramuscular vaccines
prevent disease but are less efficient in preventing infections. Mucosal vaccines can provide …
prevent disease but are less efficient in preventing infections. Mucosal vaccines can provide …
[HTML][HTML] Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition
Chimeric antigen receptor (CAR) T cell show promise in cancer treatments, but their mechanism
of action is not well understood. Decoding the mechanisms used by individual T cells …
of action is not well understood. Decoding the mechanisms used by individual T cells …
[HTML][HTML] Physiological cues involved in the regulation of adhesion mechanisms in hematopoietic stem cell fate decision
R Kulkarni, V Kale�- Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Hematopoietic stem cells (HSC) could have several fates in the body; viz. self-renewal,
differentiation, migration, quiescence, and apoptosis. These fate decisions play a crucial role in …
differentiation, migration, quiescence, and apoptosis. These fate decisions play a crucial role in …
First-generation inference accelerator deployment at facebook
…, M Kesarkar, J Killinger, B Kim, R Kulkarni…�- arXiv preprint arXiv�…, 2021 - arxiv.org
In this paper, we provide a deep dive into the deployment of inference accelerators at
Facebook. Many of our ML workloads have unique characteristics, such as sparse memory …
Facebook. Many of our ML workloads have unique characteristics, such as sparse memory …