Cell transformation assays (CTAs) have long been proposed as in vitro methods for the
identification of potential chemical carcinogens. Despite showing good correlation with rodent …

The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate
the in vivo genotoxic potential of test chemicals. This assay, however, has not previously …

As a part of the 6th IWGT, an expert working group on the comet assay evaluated critical topics
related to the use of the in vivo comet assay in regulatory genotoxicity testing. The areas …

Allura Red AC is an approved food color additive internationally with INS number 129, in
the United States as food color subject to batch certification “Food, Drug, and Cosmetic” (FD&C) …

The Mouse Lymphoma Assay (MLA) Workgroup of the International Workshop on Genotoxicity
Tests (IWGT) met on June 28th and 29th, 2002, in Plymouth, England. This meeting of the …

Tartrazine is approved as a food color additive internationally with INS number 102, in the
United States as food color subject to batch certification “Food, Drug, and Cosmetic” (FD&C) …

The Bhas 42 cell transformation assay is a sensitive short-term system for predicting chemical
carcinogenicity. Bhas 42 cells were established from BALB/c 3T3 cells by the transfection …

The Mouse Lymphoma Assay (MLA) Workgroup of the International Workshop on Genotoxicity
Test Procedures held a second harmonization meeting just prior to the US Environmental …

In vitro cell transformation assays (CTA) are used to assess the carcinogenic potential of
chemicals and complex mixtures and can detect nongenotoxic as well as genotoxic carcinogens…

The Syrian hamster embryo (SHE) assay (pH 6.7) is an in vitro candidate to replace in vivo
carcinogenicity tests. However, the conventional method of visual scoring of foci (non-…