Sulfur mustard (SM) is a strong alkylating agent, which produces subepidermal blisters,
erythema and inflammation after skin contact. Despite the well-described SM-induced gross and …

Sulfur mustard (SM) is a strong vesicant agent which has been used in several military
conflicts. Large stockpiles still exist to the present day. SM is believed to be a major threat to …

Whilst the acute effects of sulfur mustard have been relatively well characterised, the chronic
effects of short term but significant exposures are still evolving. The approximately 30,000 …

Objective: Sulfur mustard (SM) is a bifunctional alkylating substance being used as chemical
warfare agent (vesicant). It is still regarded as a significant threat in chemical warfare and …

… Enzymes that hydrolyze OPCs cleave the reactive leaving group of OPCs (eg, F or CN)
from the central phosphorus atom, initiating nucleophilic substitution by a hydroxyl group. …

Sulfur mustard (SM) is a chemical warfare agent causing blistering, inflammation and
ulceration of the skin. Thiol compounds such as glutathione (GSH) and N-acetylcysteine (NAC) …

Sulfur mustard (SM) is a vesicating chemical warfare agent causing skin blistering, ulceration,
impaired wound healing, prolonged hospitalization and permanent lesions. Silibinin, the …

Mustard agents are potent DNA alkylating agents with mutagenic, cytotoxic and vesicant
properties. They include bi-functional agents, such as sulfur mustard (SM) or nitrogen mustard (…

The transient receptor potential ankyrin 1 (TRPA1) cation channel is expressed in different
tissues including skin, lung and neuronal tissue. Recent reports identified TRPA1 as a sensor …

Sulfur mustard (SM; bis(2-chloroethyl)sulphide; HD) is a blister inducing agent causing DNA
damage and subsequently, cell death, mostly by apoptosis in basal keratinocytes. Despite …